Much of the following research is provided courtesy of EUFASD for which we are grateful.

January 2023

Nature – Initial study on quantitative electroencephalographic analysis of bioelectrical activity of the brain of children with fetal alcohol spectrum disorders (FASD) without epilepsy
The main objective of this study was to identify characteristic patterns in QEEG among individuals affected with FASD.

BMC Medicine – Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders
Our study shows the effects of early alcohol exposure on human embryonic and extraembryonic cells, introduces candidate genes for alcohol-induced developmental disorders, and reveals potential biomarkers for prenatal alcohol exposure.

The Lancet Public Health – Heavy prenatal alcohol exposure and overall morbidities: a Danish nationwide cohort study from 1996 to 2018
Heavy prenatal alcohol exposure is associated with an overall increased risk of child morbidities and previously unrecognised alcohol-related health problems. Prenatal alcohol exposure is a key public health issue with a potential negative impact on child and adolescent health. This study urges for renewed efforts and substantiates the profound degree to which pre-conceptional care is mandatory.

Logopedia Silesiana – Performance of a picture description by ten-year-olds with fetal alcohol syndrome
The subject of this paper is describing of a picture by ten-year-olds with fetal alcohol syndrome and their peers from a control group.

ResearchGate – Leveraging Community-University Partnerships to Develop a Strength-Based and Individualized Approach to Humanizing Housing Service Delivery for Individuals with Fetal Alcohol Spectrum Disorder (FASD)
This field report summarizes and advances key learnings for leveraging community–university partnerships addressing housing service gaps for high-risk, marginalized populations with complex needs.

African Journal of Primary Health Care & Family Medicine – Alcohol ban during the COVID-19 pandemic lockdown: Lessons for preventing foetal alcohol spectrum disorder in South Africa
During the two national lockdowns implemented in South Africa to curb the spread of the coronavirus disease 2019 (COVID-19) pandemic, the sale and consumption of alcoholic beverages were prohibited.

Nordic Studies on Alcohol and Drugs – Adverse childhood experiences and neurodevelopmental disorders among youth with and without prenatal substance exposure: A longitudinal matched register-based cohort study
A strong association between ACEs and neurodevelopmental disorders was found. Brain research is needed to examine whether ACEs worsen neurodevelopmental outcomes caused by PSE.

Alcoholism: Clinical and Experimental Research – Comparison of three systems for the diagnosis of Fetal Alcohol Spectrum Disorders in a community sample
These results indicate a lack of consistency in these approaches to diagnosis. Discrepancies result from differences in specifying the criteria used to define the diagnosis, including growth, physical features, neurobehavior and alcohol-use thresholds.

Journal of Affective Disorders – Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel
Overall, these results suggest that PAE enhances alcohol preference and susceptibility to PTSD through synaptic HCN1 channels in the PFC. In addition, ZD7288 may be a promising candidate for preventing alcohol-associated PTSD-like syndrome, particularly in males.

Plos one – Spatial distribution and determinants of alcohol consumption among pregnant women in Ethiopia: Spatial and multilevel analysis
Alcohol consumption during pregnancy in Ethiopia was high. The spatial distribution of alcohol consumption was significantly varied across the country.

International Journal of Molecular Sciences – Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders
Prenatal alcohol exposure can cause developmental abnormalities (fetal alcohol spectrum disorders; FASD), including small eyes, face and brain, and neurobehavioral deficits.

Developmental Neuroscience – Auditory Outcomes in Adolescents with Prenatal Alcohol Exposure
Investigate three aspects of auditory function (auditory acuity, cochlear dysfunction, and auditory processing) in adolescents with fetal alcohol exposure without phenotypic changes.

November 2022

Alcoholism Clinical and Experimental Research – MicroRNA-150-5p is upregulated in the brain microvasculature during prenatal alcohol exposure and inhibits the angiogenic factor Vezf1
miR-150-5p regulation of Vezf1 results in altered endothelial cell function during alcohol exposure. Further, miR-150-5p inhibition of Vezf1 may adversely alter the development of the cortical microvasculature during PAE and contribute to deficits seen in patients with FASD.

Child & Family Social Work – ‘It’s rewarding because I get the love’: Grandparents raising grandchildren with foetal alcohol spectrum disorder
Grandparents raising their grandchildren with FASD face challenges and thus require specific supports so that they may adequately provide a safe and nurturing home environment for children with often challenging learning and social needs.

Ophthalmic Epidemiology – Eye Abnormalities in Children with Fetal Alcohol Spectrum Disorders: A Systematic Review
Examination of eyes and vision should be considered in children with PAE and suspected or diagnosed FASD to enable early identification and optimal management. – Evidence synthesis – Accuracy of administrative database algorithms for autism spectrum disorder, attention-deficit/hyperactivity disorder and fetal alcohol spectrum disorder case ascertainment: a systematic review
There is some evidence to suggest that cases of ASD and ADHD can be identified using administrative data; however, studies that assessed the ability of algorithms to discriminate reliably between cases with and without the condition of interest were lacking. No evidence exists for FASD.

Fetal Alcohol Spectrum Disorders – Comparative Analysis of Physical Traits of Children with Fetal Alcohol Spectrum Disorders in South Africa and the United States and the Likelihood of FASD Births
The prevalence of fetal alcohol spectrum disorders (FASD) in recent years was 29% among children in the Western Cape Province of South Africa and 6.5% in four regions of the United States.

Alcoholism Clinical and Experimental Research – The impact of prenatal alcohol and/or tobacco exposure on brain structure in a large sample of children from a South African birth cohort
PAE was associated with reduction in structure of the medial temporal lobe, a brain region critical for learning and memory. PTE had stronger and broader associations, including with regions associated with executive function, reward processing, and emotional regulation, potentially reflecting continued postnatal exposure to tobacco (i.e., second-hand smoke exposure).

Alcoholism Clinical and Experimental Research – Early developmental alcohol exposure alters behavioral outcomes following adolescent re-exposure in a rat model
These results indicate that combined exposure to alcohol during these two critical periods reduces anxiety-related behaviors and/or increases risk taking in a sex-dependent manner, suggesting that prenatal alcohol exposure may affect risk for emotional consequences of adolescent alcohol exposure.

Fetal Alcohol Spectrum Disorder – Alcohol Use Screening in Pregnant and Childbearing Aged Women: Practices and Implications
Increased use of these strategies would reduce risk of adverse outcomes to women and their children, decrease new cases of FASD and recurrence of FASD in families, and thus would improve maternal and child health.

American Journal of Perinatology – The Impact of Self-Reported Alcohol, Tobacco, and Recreational Drug Use during Pregnancy on Adverse Pregnancy Outcomes in First-Time Mothers
Trajectories of substance use are associated with APOs; thus, interventions to mitigate the use when encountered early in pregnancy are warranted.

Int J Environ Res Public Health – Preventing Drift through Continued Co-Design with a First Nations Community: Refining the Prototype of a Tiered FASD Assessment
This study emphasised the benefit of continued co-design to ensure health implementation strategies match the needs of the community.

Alcohol – Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders
This is the first study to show that ethanol exposure sustains tau Threonine231 phosphorylation in the perinatal hippocampus regardless of Total Tau expression.

Cureus – Fetal Alcohol Spectrum Disorder in a Newborn. Our objective was to evaluate a three-day-old male infant born at 37 weeks gestation via vaginal delivery to a mother with admitted excessive alcohol intake for FASD. On physical appearance, the newborn had evidence of smooth philtrum and thin vermillion border, which are two of the three cardinal facial characteristics for dysmorphology.

Alcoholism: Clinical and Experimental Research – Fetal Alcohol Spectrum Disorders and access to Regional Center Services in San Diego County
The 6.9% prevalence estimate among Regional Center clients was higher than the prevalence estimate of 2.3% in the same community among 5–7-year-old children in the general population.

African Journal of Reproductive Health – Barriers and facilitators of alcohol abstinence during pregnancy
There is a limited understanding of why pregnant women drink in the South African context, particularly in rural settings, where the prevalence of FASD is highest.

City University of Seattle – Fetal Alcohol Spectrum Disorder (FASD): Examining How School Counsellors Can Support Students Diagnosed with FASD Through Life Skills and Social-Emotional Learning. The research question I will addressed in this capstone is: How can school counsellors support students diagnosed with fetal alcohol spectrum disorder through life skills and social-emotional learning?

SSRN – Maternal Alcoholism Affects Cell Lineage in Adult Hippocampal Neurogenesis. These results suggest that pathways implicated in cell determination were affected by PEE and remained affect in adulthood.

Laurier – “The system is not set up for individuals with FASD”: Lived and Caregiver Perspectives Regarding Current and Ideal Housing Supports for Canadian Adults with Fetal Alcohol Spectrum Disorder. This study offers insight into the perspectives of adults with FASD regarding their daily living support, which is critical to inform future supported housing and support self-determination.

AAIDD – The Strengths and Positive Influences of Children With Fetal Alcohol Spectrum Disorders
This study is the first to examine strengths and positive influences of young children with fetal alcohol spectrum disorder (FASD).

Drug and Alcohol Review – Evaluation outcomes of an alcohol and pregnancy campaign targeting multiple audiences. Results indicate the campaign was well received by respondents, increased concern about drinking alcohol during pregnancy and positively influenced women’s intentions to refrain from drinking while pregnant.

Biomedicines – Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol. These findings indicate that the impact of PAE on transcriptional regulation of synucleins may be sex-dependent, and in males’ disruption in α-synuclein mRNA expression may contribute to increased vulnerability to alcohol-associated behavior.

Substance Abuse Treatment, Prevention, and Policy – Effectiveness of a practice change intervention in reducing alcohol consumption in pregnant women attending public maternity services. Special occasion drinking was reduced following implementation of guideline-recommended care. Failure to change other patterns of alcohol use in pregnancy may reflect barriers to implementing the model of care in antenatal care settings and the need to address other social determinants of alcohol use.

Child Psychiatry & Human Development – Characteristics of the Symptoms of the Proposed ND-PAE Disorder in First Grade Children in a Community Sample. The proposed symptoms for Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE) were evaluated in children who participated in the Collaboration on Fetal Alcohol Spectrum Disorders Prevalence study.

Dialogues in Health – Prevention of alcohol related harm though preconception care: A scoping review of barriers and enablers. Investment in alcohol education and skills training for healthcare professionals is required to ensure a coherent message is communicated across services, and that shared decision making about healthcare between service users and health professionals is facilitated.

Journal of Karnali Academy of Health Sciences – Alcohol Consumption during Pregnancy and its association with Fetal Outcome in a Mountainous District of Nepal. The prevalence of alcohol consumption during pregnancy was seen in one out of three mothers. Mothers were at the highest risk of delivering low birth weight babies if they had a binge alcohol consumption pattern.

Frontiers – How the alcohol industry fought against pregnancy warning labels in France. A press coverage analysis spanning 20 years. This study fills a gap in the Anglosphere research on lobbying against alcohol warnings by analyzing lobbyists’ arguments over a 20-year period covering both failed and successful industry lobbying.

Qualitative Health Research – Researching Alcohol Consumption During Pregnancy. Opportunities and Challenges With Two Methods of Data Acquisition. These results have implications for research about female substance use. Knowledge of the issues will bestow a valuable contribution to researchers working in the field of substance use to help develop appropriate research approaches, as they engage in research into this highly stigmatized and controversial area.