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Rffada acknowledges and thanks the work of EUFASD in sourcing and compiling international research.

EUFASD & Research 9 June 2024

Nature – Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood
Therefore, we conclude that even moderate exposure to alcohol prenatally has long-lasting effects on brain function during reward processing and risk of cannabis use in young adulthood. https://www.nature.com/articles/s41398-024-02941-9

SSRN – “People Talk About Fasd Diagnosis But Barely Any Young People are Asked About It”:  Diagnosis Perspectives and Disability Identity in Adolescents with FASD. The views expressed by adolescents with FASD about the impact of the FASD diagnosis, and the disability identity process, were similar to other groups of young people with different neurodevelopmental and physical conditions.

Research in Developmental Disabilities – Positive behavior support (PBS) with children with fetal alcohol spectrum disorders: Characterizing caregivers’ use of PBS using follow-up clinical trial data. This study is the first to characterize caregivers’ use of PBS strategies for children with FASD using mixed methods. Problem behaviors such as rule breaking were more difficult to target.

Children and Youth Services Review – ‘Trying differently’ towards improving school experiences: Systematically reviewing research on school experiences for students with Fetal Alcohol Spectrum Disorder (FASD) and their teachers.  Key findings are discussed, and important recommendations are made for researchers, policymakers, and educators to address the longstanding gaps in research and practice regarding the complex care and support needs of those with FASD from an anti-oppressive, destigmatized, and holistic framework.

Anatomy & Cell Biology – Alcohol intake during pregnancy reduces offspring bone epiphyseal growth plate chondrocyte proliferation through transforming growth factor β-1 inhibition in the Sprague Dawley rat humerus. Intrauterine alcohol exposure delays bone maturation and intensifies osteoporosis and fracture risk. As most studies emphasize the neurological aspects of intrauterine alcohol exposure, there is a lack of research on the implications pertaining to osseous tissue.

International Journal of Molecular Sciences – Fetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders (FASDs). Because several microRNAs (miRNAs) are implicated in other neurological and neurodevelopmental disorders, the effects of EtOH exposure on the expression of these miRNAs and their target genes and pathways were assessed.

Drug and Alcohol Review – Evaluation of the Fetal Alcohol Spectrum Disorder Hub Australia website. Users found the FASD Hub accessible, authoritative and useful and suggested improvements.

Behavioral Sciences – Effects of Developmental Timing on Cognitive and Behavioral Profiles in Fetal Alcohol Spectrum Disorder: Considerations for Education. This study aims to generate a profile of executive and behavioral functioning in children and adolescents diagnosed with FASD.

Reproductive Toxicology – Contribution of ferritin and zinc to adverse infant outcomes among pregnancies with prenatal alcohol exposure in South Africa. Nutritional status during pregnancy can impact fetal development, yet less is known about how alcohol may interact with nutritional status to influence infant outcomes.

Duke University – Sociodemographic and Psychological Profiles of Pregnant Women Who Consume Alcohol in Moshi, Tanzania: A Latent Class Analysis. Understanding variations in alcohol use among unique subgroups of pregnant women is essential for the development of targeted interventions to alleviate the burden of alcohol use during pregnancy.

The main research objective of this dissertation was to better understand the policy, predisposing and enabling factors related to prenatal alcohol and substance use among the American Indian/Alaska Native (AI/AN) birthing population in the United States.

Alcohol Clinical and Experimental Research – Prenatal ethanol and cannabis exposure have sex- and region-specific effects on somatostatin and neuropeptide Y interneurons in the rat hippocampus. These results illustrate how alcohol and cannabis exposure in utero may affect hippocampal function by altering inhibitory processes in a sex-specific manner. https://onlinelibrary.wiley.com/doi/full/10.1111/acer.15350

Acta Obstetricia et Gynecologica Scandinavica – Screening of substance use in pregnancy: A Danish cross-sectional study
Substance use among pregnant women consisted mainly of nicotine. Dipstick screening involved risks of false negatives and false positives.

Nutrient – Prenatal Exposures, Diagnostic Outcomes, and Life Experiences of Children and Youths with Fetal Alcohol Spectrum Disorder
Children and youths diagnosed with FASD may experience a range of adverse health and social outcomes. This cross-sectional study investigated the characteristics and outcomes of children and youths diagnosed with FASD between 2015 and 2018 at the Sunny Hill Centre in British Columbia, Canada and examined the relationships between prenatal substance exposures, FASD diagnostic categories, and adverse health and social outcomes.

EUFASD & Research 19 May 2024

Nature – Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders. A hallmark of fetal alcohol spectrum disorders (FASD) is neurobehavioral deficits that still do not have effective treatment. Here, we present that reduction of Apolipoprotein E (APOE) is critically involved in neurobehavioral deficits in FASD. https://www.nature.com/articles/s41380-024-02586-6

European Child & Adolescent Psychiatry – Qualitative study of the lived experience of methylphenidate prescribed for children with a fetal alcohol spectrum disorder. This study aims to explore the lived experience of children with FASD taking MPH and their caregivers to adapt prescribing modalities by considering different ways to administer the drugs. https://link.springer.com/article/10.1007/s00787-024-02457-z

Applied Neuropsychology: Child – An examination of executive functioning in adolescents with FASD in a self-regulation intervention
These findings highlight the potential of the SR intervention to positively impact EF in adolescents with FASD. This study contributes to the growing literature that demonstrates the potential of individuals with FASD to benefit from direct intervention.

Biomolecules – Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental  Pathways Associated with Risk of FASD Outcomes. In this study, using a candidate gene approach, we performed a genetic variant analysis of retinoic acid (RA) metabolic and developmental signaling pathway genes on whole exome sequencing data of 23 FASD-diagnosed individuals.

Journal of Forensic Psychology Research and Practice – Innovating Services for Justice-Involved Individuals with Fetal Alcohol Spectrum Disorder: The In Reach Project
Fetal Alcohol Spectrum Disorder (FASD) is a term describing the range of neurocognitive, physical, behavioral, and learning difficulties resulting from prenatal alcohol exposure. Individuals with FASD are at an increased risk, relative to those without FASD, for justice system involvement.

Journal of Affective Disorders – Prevalence of co-occurring diagnoses in people exposed to alcohol prenatally: Findings from a meta-analysis
Co-occurring diagnoses are extremely prevalent in people with PAE, with older individuals, females, and those diagnosed with FASD being most at risk for having a co-occurring disorder. https://www.sciencedirect.com/science/article/pii/S0165032724007535

Series of endocrinology, diabetes & metabolism – Growth hormone therapy in a child with fetal alcohol syndrome: personal experience with literature review. GH therapy in children with FAS may lead to an improvement in growth rate and an increase in final height, although, this condition is not included in the specific recommendations for use of GH.

Alcohol: Clinical and Experimental Research – Influence of childhood trauma and traumatic stress on a woman’s risk of having a child with a fetal alcohol spectrum disorder. No direct influence of maternal childhood trauma on FASD diagnosis could be demonstrated. However, maternal trauma may indirectly contribute to the risk of having a child diagnosed with FASD.

Frontiers in Neural Circuits – Effects of prenatal alcohol exposure on the olfactory system development
These findings suggest that the timing, duration, and extent of fetal alcohol exposure can yield diverse effects on olfactory system development.

Alcohol: Clinical and Experimental Research – Lower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in children. This study demonstrates PAE-related functional connectivity impairments in functional networks involved in number processing. https://onlinelibrary.wiley.com/doi/full/10.1111/acer.15332

medRxiv – Trends in fetal alcohol spectrum disorder (FASD) research: a systematic scoping review and bibliometric analysis
We conducted a systematic scoping review and bibliometric analysis to describe trends in the volume and characteristics of original research on FASD published between 2000–2023 (Review 1). https://www.medrxiv.org/content/10.1101/2024.04.29.24306557v1

Alcohol: Clinical and Experimental Research – Current and ideal living arrangements and supports for Canadian adults with fetal alcohol spectrum disorder: Part II—Perspectives from caregivers. This study explores caregivers’ perspectives regarding living support needed by adults with FASD, which can inform support programs and housing services. https://onlinelibrary.wiley.com/doi/full/10.1111/acer.15337

Children – The Fetal Alcohol Spectrum Disorders—An Overview of Experimental Models, Therapeutic Strategies, and Future Research Directions. Since the establishment of a clear link between maternal alcohol consumption during pregnancy and certain birth defects, the research into the treatment of FASD has become increasingly sophisticated. https://www.mdpi.com/2227-9067/11/5/531

Social Work Education – Advancing social work curriculum to challenge FASD-related stigma and promote strengths-based family engagement
The need for professionals to become educated in fetal alcohol spectrum disorder (FASD) has emerged as a critical topic in child and family settings.

bioRxiv – Altered markers of brain metabolism and excitability are associated with executive functioning in young children exposed to alcohol in utero
Here, we present the first study of PAE-related brain metabolite differences in early childhood (ages 3-8 years) and their associations with cognitive performance, including executive functioning (EF) and pre-reading skills.

Alcohol – The histamine H3 receptor inverse agonist SAR-152954 reverses deficits in long-term potentiation associated with moderate prenatal alcohol exposure. Previous work from our group demonstrated deficits in long-term potentiation (LTP) of excitatory synapses on dentate gyrus granule cells in adult offspring of rat dams that consumed moderate levels of alcohol during pregnancy.

Anais da Academia Brasileira de Ciências – Neonatal outcomes associated with tobacco, alcohol, and crack use during pregnancy in three Neonatal Intensive Care Units. Our results underscore the substantial impact of maternal substance use on NICU-admitted infants, emphasizing the necessity for targeted interventions that address both neonatal health and maternal well-being, thereby underscoring the crucial role of comprehensive care in NICU settings. https://www.scielo.br/j/aabc/a/sBKLV9NP3krmDbmTpPtG7xB/?lang=en

Social Work in Public Health – Reporting on Health Care and Social Service Provider Approaches to Promoting Alcohol Abstinence During Pregnancy. The purpose of this study was to explore the current practices of HCPs and SSPs when discussing alcohol use during pregnancy, and to understand their rationale for their specific recommendations. https://www.tandfonline.com/doi/abs/10.1080/19371918.2024.2323136

BMC Public Health – Maternal smoking, consumption of alcohol, and caffeinated beverages during pregnancy and the risk of childhood brain tumors: a meta-analysis of observational studies. Maternal passive smoking, consumption of caffeinated beverages during pregnancy should be considered as risk factors for CBTs, especially glioma. https://link.springer.com/article/10.1186/s12889-024-18569-9

Frontiers in Pediatrics – Unveiling the Hidden Risk: Paternal Smoking and Alcohol Exposure Prior to Conception as Independent Factors for Allergic Rhinitis in Children. Paternal smoking and alcohol consumption prior to conception contribute to an increased risk of allergic rhinitis in children, with the risk being dependent on the dosage and duration of exposure. https://www.frontiersin.org/articles/10.3389/fped.2024.1394400/abstract

Disabilities – FASD: The Living Experience of People with Fetal Alcohol Spectrum Disorder—Results of an Anonymous Survey
By surveying those with FASD, this work expanded upon prior survey work which illustrated a multitude of early-onset physiological issues occurring at rates much higher than is typical of the general population. https://www.mdpi.com/2673-7272/4/2/22

EUFASD & Research 14 April 2024

Nature – Low to moderate prenatal alcohol exposure and neurodevelopment in a prospective cohort of early school aged childrenEvidence is strong for adverse

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EUFASD & Research News 25 March 2024

University of New Mexico – Elevation of miR-150-5p in Brain Microvascular Endothelial Cells as a result of Prenatal Alcohol Exposure is Mediated by

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05 Mar 2023


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Research – EUFASD News 11 Feb 2024

Advances in Pediatric Research – Washington and Alaska Statewide Fetal Alcohol Spectrum Disorder Diagnostic Clinical Networks: Comparison of Three Decades of 4-Digit Code

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26 Nov 2023

Windsor Yearbook of Access to Justice – Bound by Blame: Sentencing, Colonialism, and Fetal Alcohol Spectrum DisorderGladue and Ipeelee send important messages to

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12 Nov 2023

Gladue and Ipeelee send important messages to judges, but messages that have tensions within them that reflect the broader tensions of using

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